First major development in the treatment of chronic kidney disease in 20 years


WAUSAU, Wisconsin (WSAW) – Chronic kidney disease is a life-threatening disease that is severely underdiagnosed and affects an estimated 37 million, or 1 in 7 American adults. With limited treatment options, a new therapy for people with CRF is crucial to slow the progression of the disease. For this reason, the new therapy recently approved by the FDA for the treatment of CRF in patients at risk of progression with and without type 2 diabetes is of great concern to this patient population.

CKD is a progressive disease, and people with CKD are at increased risk of heart disease. However, most patients do not know they have CRF, in large part because it is a “silent” illness, and most patients will experience no symptoms until the disease progresses. While approximately 15% of adults in the US live with CKD, 9 in 10 don’t know they have it.

A new treatment option, FARXIGA® (dapagliflozin), has been shown to slow the progression of CKD – ​​a major scientific innovation for CKD patients who are at risk of progression with and without T2D. This approval marks the most significant advance in the treatment of CRF in over 20 years.

Because CKD can be missed until symptoms develop at an advanced stage, it is especially important to understand the risk factors and the serious complications that can occur.

CKD tends to worsen over time. The earlier treatment starts, the better the patient outcomes will be.

As always, talk to your doctor about your treatment options and whether FARXIGA® (dapagliflozin) is right for you.

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Important Safety Information for FARXIGA® (dapagliflozin) 5 mg and 10 mg tablets

Do not take FARXIGA if you:

  • are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include a rash, raised red spots on your skin (hives), swelling of the face, lips, tongue, and throat, which can cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your doctor or go to the nearest hospital emergency department straight away
  • are on dialysis

What are the possible side effects of FARXIGA?

FARXIGA can cause serious side effects including:

  • Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition that may require hospitalization and can lead to death. Symptoms can include nausea, tiredness, vomiting, difficulty breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your doctor straight away. If possible, check your urine or blood for ketones, even if your blood sugar is less than 250 mg / dL
  • DehydrationThis can make you dizzy, weak, light-headed, or faint, especially when you stand up. There have been reports of sudden kidney injury in people with type 2 diabetes taking FARXIGA. You may be at a higher risk of dehydration if you take medications to lower your blood pressure, including water pills. are 65 years of age or older; are on a low-salt diet or have kidney problems.
  • Severe urinary tract infections: Some who lead Hospitalizations have occurred in people taking FARXIGA. Tell your doctor if you have signs or symptoms of a urinary tract infection, including a burning sensation when urinating, urinating frequently, urinating immediately, pain in the lower part of your stomach (pelvis) or blood in the urine with or without a fever, back pain, nausea or vomiting
  • Low blood sugar may occur if you take FARXIGA with another medicine that can cause low blood sugar, e.g. B. sulfonylureas or insulin. Symptoms of low blood sugar include shaking, sweating, rapid heartbeat, dizziness, hunger, headache, and irritability.
  • Bacterial infections under the skin of the genitals and their surroundings. Rare but serious infections have occurred with FARXIGA that cause severe tissue damage under the skin of the genitals and around them. This infection has occurred in both women and men and can lead to hospitalizations, surgery, and death. See a doctor right away if you have a fever or feel very weak, tired, or unwell, and if you develop pain or tenderness, swelling, or redness of the skin on the genitals and areas around them

The most common side effects of FARXIGA are Yeast infections of the vagina or penis and changes in urination, including an urgent need to urinate more often, in large quantities, or at night.

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